机械增强可注射水凝胶《ACS Applied Polymer Materials》

机械增强可注射水凝胶

【摘要】

由于可注射水凝胶能够通过微创途径传递到靶点，因此其在生物医学应用中受到了重要的研究关注。然而，鉴于此类水凝胶的可注射性和强力学之间的固有张力，这些材料的实际应用受到通常可实现的相对较弱的力学性能的限制。在这篇聚焦文章中，我们描述了通过三种主要策略开发可注射水凝胶机械增强方法的最新进展：操纵凝胶浓度/功能化，使用双重/互穿网络结构，以及将纳米粒子/纳米纤维增强剂纳入凝胶基质。我们特别强调了使用化学原位正交凝胶反应对和纤维素纳米晶体作为各向异性纳米粒子增强剂，开发具有显著机械增强、改进剪切变稀和原位生成各向异性的可注射水凝胶。

【关键词】可注射水凝胶，机械增强，水凝胶浓度/功能化，双/互穿网络，纳米粒子/纳米纤维复合水凝胶，纤维素纳米晶体

Mechanically Reinforced Injectable Hydrogels

Kevin J. De France, Emily D. Cranston, and Todd Hoare*

Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton ON L8S 4L8, Canada

ACS Appl. Polym. Mater. 2020, 2, 3, 1016–1030

Publication Date: December 4, 2019

https://doi.org/10.1021/acsapm.9b00981

Abstract

Injectable hydrogels have garnered significant research attention in biomedical applications due to their ability to be delivered to a target site via a minimally invasive route. However, given the inherent tension between injectability and strong mechanics in such hydrogels, the practical use of these materials is limited by the relatively weak mechanical properties typically achievable. In this spotlight article, we describe recent progress in developing approaches for the mechanical reinforcement of injectable hydrogels via three major strategies: manipulating gel concentration/functionalization, using a double/interpenetrating network structure, and incorporating nanoparticle/nanofiber reinforcing agents into the gel matrix. We particularly highlight our work on using chemically orthogonal in situ-gelling reactive pairs and cellulose nanocrystals as anisotropic nanoparticle reinforcing agents to develop injectable hydrogels with significant mechanical enhancement, improved shear thinning, and in situ-generated anisotropic properties.

KEYWORDS: injectable hydrogels, mechanical reinforcement, hydrogel concentration/functionalization, double/interpenetrating networks, nanoparticle/nanofiber composite hydrogels, cellulose nanocrystals

来源：《ACS Applied Polymer Materials》

声明：中文翻译如与英文原文有差异，请以英文为准。所有注明来源的稿件，文章内容仅代表作者观点，本平台转载出于传递更多信息及方便行业探讨之目的，并不意味着本平台赞同其观点或证实其内容的真实性，文章内容仅供学习研究参考。